cll 13q deletion life expectancy

When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. . SEER. Balatti V, Croce CM. This chromosome abnormality is most commonly associated with the myelodysplastic syndrome.. Chemotherapy: Chemotherapy fights cancer with drugs that are taken orally or intravenously. This segment encodes several proteins that regulate cell proliferation and the cell cycle, such as SMAD9 and RB1; both are involved in the signal transduction pathway of transforming growth factor-beta (TGF-, an important . CONCLUSION: In CLL with del(13q), a subset of patients progress after FCR therapy and have poor PFS. 2012 Summer;42(3):313-7. Living as a chronic lymphocytic leukemia survivor. Overall 38% (n=51) patients experienced disease progression. CLL Societys tax ID number is 46-4131354. Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia. Chronic B-cell leukemias and Agent Orange - public health. -. Typical treatment of chronic lymphocytic leukemia. Hence, it is imperative to get information about individual patient prognosis in order to define a therapeutic strategy and to allow patients to plan their lives moving forward. American Cancer Society. 13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia. The most frequent are heterozygous and homozygous 13q deletions (44%), but also alterations such as trisomy 12 and 17p deletions have been detected (Fazi et al. In conclusion, the deletion of 13q varied in size both in CLL and in other BCLPDs and adversely influenced the prognosis of patients with other BCLPDs. ASH 2022: Dr. Talha Munir on How IGHV Mutation Status of Chronic Lymphocytic Leukemia (CLL) Affects Response to Combination Ibrutinib Plus Venetoclax, ASH 2022: Final Analysis of the Prospective Multicenter CLL2-Give Trial of Obinutuzumab, Ibrutinib, and Venetoclax in Untreated Patients with CLL with 17p Deletion/TP53Mutation, CLL Societys COVID-19 Update for the Week of February 20, 2023, Karen Jones on Warm Autoimmune Hemolytic Anemia and wAIHA Warriors, 4) Deletions on the short arm of chromosome 17 (del(17p)). Dal Bo M, Rossi FM, Rossi D, Deambrogi C, Bertoni F, Del Giudice I, Palumbo G, Nanni M, Rinaldi A, Kwee I, Tissino E, Corradini G, Gozzetti A, Cencini E, Ladetto M, Coletta AM, Luciano F, Bulian P, Pozzato G, Laurenti L, Forconi F, Di Raimondo F, Marasca R, Del Poeta G, Gaidano G, Fo R, Guarini A, Gattei V. Genes Chromosomes Cancer. Br J Haematol. This cookie is set by GDPR Cookie Consent plugin. Survival rate for chronic lymphocytic leukemia. Disclaimer. 2001 Jun;15(6):981-6. doi: 10.1038/sj.leu.2402125. 2012;122:34323438. Moreover, female patients and younger patients had a . (2018). Leukemia and Lymphoma Society. Self-care will vary for different people. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Bookshelf About half of CLL patients have this change. We analyzed this group of patients treated with FCR to characterize the relationship between clinico-biological parameters and outcome. The authors have declared that no competing interests exist. However, you may visit "Cookie Settings" to provide a controlled consent. What is chronic lymphocytic leukemia? Originally published inThe CLL Tribune Q3 2017. Copyright 2023 by American Society of Hematology, 642. Disclaimer. FOIA HHS Vulnerability Disclosure, Help If you are greater than 2% different you are"mutated" while those that are less than 2% are "unmutated.". cll 13q deletion life expectancyplymouth township mi police scanner. Finding out that you or a loved one has CLL may take your breath away. The .gov means its official. Can diet help improve depression symptoms? (2020). Chronic lymphocytic leukemia stages. Chemotherapy, combined with monoclonal antibody treatment, is a standard protocol used for fighting this disease. Although CLL with 13q deletion as the sole cytogenetic abnormality . Those under the age of 40 are unlikely to experience this type of cancer. Of 51 patients who experienced disease progression, there were 8 observed deaths. The cookie is used to store the user consent for the cookies in the category "Other. Epub 2011 May 11. 13q was the best bucket, 17p the worst, trisomy 12 and 11q in between, whatever those numbers and letters meant (see FISH test for dummies). Around 85% of people with chronic lymphocytic leukemia (CLL) live for 5 or more years following diagnosis. 8600 Rockville Pike However, it is possible to live for 10 years or more after diagnosis. The treatments youre going through may also make you feel very tired, or ill. Youll probably have good days and bad days. Administration UD of VA Veterans Health. We also discuss how to achieve a good quality of life with CLL. 1 Specific genomic aberrations have been identified in CLL; the most frequent chromosomal abnormality is deletions of 13q, followed by deletions of 11q, trisomy 12, and deletions of 17p and 6q. Eighty nine (66%) had beta-2 microglobulin (2M) <4 and 44 (33%) > 4 g/mL. How do doctors diagnose chronic lymphocytic leukemia? What is the latest research on the form of cancer Jimmy Carter has? CLL accounts for around one-quarter of new leukemia cases. Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. White blood cells are an integral part of your immune system. 2017;92:864869. Asterisk with author names denotes non-ASH members. Treatments include: Watch and wait: If youre in a low-risk stage and have no outward symptoms, watchful waiting may be the first recommended course of action. Summary. (2022). 2020 Apr 28;10(4):45. doi: 10.1038/s41408-020-0310-9. Survival rates are estimates, based on large numbers of people. Due to recent exponential progress in therapeutic options and identification of novel prognostic markers in CLL, the existing clinical staging systems (i.e Rai and Binet staging) have not been able to accurately identify prognostic subgroups. Forty-one percent reported concerns about their quality of life, 40 percent were worried about finances and . Wierda: The University of Texas MD Anderson Cancer Center: Employment; Sanofi: Consultancy, Honoraria; Kite: Research Funding; Karyopharm: Research Funding; Emergent: Consultancy, Honoraria, Research Funding; Janssen: Research Funding; Genentech/Roche: Consultancy, Honoraria, Research Funding; GSK/Novartis: Consultancy, Honoraria, Research Funding; Gilead: Consultancy, Honoraria, Research Funding; Acerta: Research Funding; Merck: Consultancy, Honoraria; Genzyme: Consultancy, Honoraria; Pharmacyclics: Consultancy, Honoraria, Research Funding; AbbVie: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria; Juno: Research Funding. 3 NCI data for that same time frame show a decline in the new case rate and death rate . They can also indicate many other conditions. The level of risk helps to determine the best CLL management when used with other newer prognostic factors. After 5 years, they look at data on the same group of people. The survival rate for CLL is better than for many other types of cancer. Chronic lymphocytic leukemia (CLL) is the most prevalent type of adult leukemia and is defined by a typical immunophenotype of mature B-cell markers (CD19, CD20[dim], CD23, sIg [dim]) with coexpression of the T-cell marker CD5. The minimal deleted region (MDR)/small deletion or long 13q loss/mutation, and biallelic 13q deletion or monoallelic 13q deletion are commonly seen. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Schnaiter A, Stilgenbauer S. 17p deletion in chronic lymphocytic leukemia: risk stratification and therapeutic approach. 2014 Sep;53(9):788-97. doi: 10.1002/gcc.22188. CLL may cause fatigue. 2018 Jun;181(5):604-613. doi: 10.1111/bjh.15239. Except for Hb <10 gm/dl (p=0.001), none of other parameters had statistically significant impact on OS. However, reproducibility and standardization of these markers in various laboratories across the country have led to their tempered utility. The life expectancy corresponds to that of the normal population, which is why regular follow-ups are not recommended. Try to include good sleep, exercise, and social time with people you love in your self-care plan. Learn about CLL diagnosis, staging, symptoms, and, Atypical chronic myeloid leukemia is a blood and bone marrow cancer. Landau D, Tausch E, Taylor-Weiner A, et al. 2 Monoallelic 13q14 deletions are present in nearly 70% of patients with CLL, while biallelic and . SNP array analysis revealed the common deletion of a 15 Mb (13.3 to 14.3) region of 13q in 7 13q and 13q patients. Federal government websites often end in .gov or .mil. The stage of leukemia is an important factor in life expectancy. 2012;21(1):67-77. doi:10.1111/j.1365-2354.2011.01278.x, Pulte D, Castro FA, Jansen L, et al. Combined somatic mutation and copy number analysis in the survival of familial CLL. . Epub 2010 Oct 26. Key statistics for chronic lymphocytic leukemia. A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease. 2013. In HELIOS, pts with R/R CLL/SLL (excluding del17p) received BR (6 cycles) with or without ibr 420 mg/day (starting on day 2 of cycle 1) followed by single-agent ibr or placebo continued until PD or tox. No matter what the future brings, try not to go through it alone. Finding out as much as possible about CLL and consulting with a doctor on how to lead a healthy lifestyle can help with decisions about treatment and care. It is not a mutation or genetic change in one gene, but rather am extra chromosome, which is the structure that holds your genetic material. N Engl J Med. Many people find living with a lifelong condition challenging. These are very much chronic leukemias just as much as a chronic lymphocytic leukemia or a chronic myeloid leukemia. Your CLL prognosis will vary from that of other people with this condition. Genes Chromosomes Cancer. CLL Society is a registered 501(c)(3) tax-exempt nonprofit organization. Approximately 3% to 10% of CLL patients have the 17p deletion at diagnosis, and it occurs in 30% to 50% of patients with relapsed/refractory CLL, according to the manufacturer. Hallek M, Cheson BD, Catovsky D, et. The average age of onset for chronic lymphocytic leukemia is 70. Interestingly NOTCH1 mutation was independently associated with Richters transformation (conversion of CLL to an aggressive lymphoma). Stevens-Kroef MJ, van den Berg E, Olde Weghuis D.Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling. 2011 Aug;50(8):633-43. doi: 10.1002/gcc.20885. Castro JE, Melo-Cardenas J, Urquiza M, Barajas-Gamboa JS, Pakbaz RS, Kipps TJ. (2018). ~Del(13q) is one of the most common chromosomal abnormalities in CLL. Treatment focuses on stopping or slowing down the spread of CLL. Bethesda, MD 20894, Web Policies People with early-stage disease who are watching and waiting may find it stressful to not pursue treatment. All articles and interviews are informational only, should never be considered medical advice, and should never be acted on without review with your health care team. Cutting-edge treatments, including the use of monoclonal antibodies (mAbs, proteins made in a lab to fight infection) and targeted therapies (using drugs or other substances to identify and attack certain cancer cells), are helping people live longer and with fewer symptoms than in decades past. This patient has trisomy 12, which was sort of . . Chronic Myeloid Leukemia vs. Leukemia. Unauthorized use of these marks is strictly prohibited. 2017 Aug;92:864-869. doi: 10.1016/j.biopha.2017.05.144. Malsegregation of the paternal insertional translocation involving chromosome 12 and 13 resulted in a 13q deletion syndrome of the child [46,XY,ins(12;13)(q21.2;q12.3q14.3)]. CLL International Prognostic Index (CLL-IPI). 2015;526(7574):525-530. Due to small number of observed events, estimated survival rates could not be ascertained meaningfully. 2008 Oct;49(10):1887-92 Verywell Health's content is for informational and educational purposes only. A huge reason for this is the identification of prognostic factors which throw more light into the heterogeneous biology of the disease. To diagnose CLL, your doctor will conduct a physical exam to look for lymph node swelling and abdominal pain. National Cancer Institute. sharing sensitive information, make sure youre on a federal Braga TV, Evangelista FC, Gomes LC, Arajo SS, Carvalho MD, Sabino AP. CD38, CD49d and Zap-70 are flow cytometry-based markers, however CD49d is more important than the other two, since it has an impact on prognosis independent of FISH tests or IGHV mutation status. It has been shown in studies to be as effective as aggressive treatments during early CLL stages. Features that often occur in people with . Chronic lymphocytic leukemia treatment (PDQ®) patient version. Occasionally you get a case where you are at 1.9% different. Dhner H, Stilgenbauer S, Fischer K, Bentz M, Lichter P. Kim H, Hur M, Moon HW, Park CM, Yun YM, Kim SY. cajunjeff 2 years ago. CLL is not curable. The investigators concluded that survival rates significantly improved among patients diagnosed after 2004 who were treated during the era of advanced CLL therapies. People can live with CLL for many years after diagnosis, and some can live for years without the need for treatment. Karyotype was diploid in 107 (80%) patients and abnormal in 16 (12%) patients. Patients with renal dysfunction can have falsely elevated levels and hence, caution must be interpreted in this particular situation. However, survival rates for this cancer are good, particularly with early diagnosis and treatment. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". Doctors can very rarely cure CLL. Having correct information can give a person more control and understanding. Chronic Lymphocytic Leukemia: What Are the Differences? Usually del11q is generally seen in young male patients and tends to present with bulky lymph nodes. All rights reserved. An 87% 5-year survival rate means that around 87 out of every 100 people with CLL will be alive 5 years after diagnosis. Blood 2017; 130 (Supplement 1): 5337. doi: https://doi.org/10.1182/blood.V130.Suppl_1.5337.5337. We have a couple of other markers to additionally kind of distinguish them. 2% is the magical number. Corey Whelan is a patient advocate with a decades-long background in reproductive health. Deletion of 13q14 [del(13q)] is the most common cytogenetic change (50%) in chronic lymphoblastic leukemia (CLL), and it is a good prognostic factor if it is detected as a sole aberration by FISH. Strati P, Keating MJ, O'Brien SM, et al. When a doctor examines an individual at regular appointments, they have the chance to check for signs that CLL may be returning and treat it quickly. Another indicator is that your blood may also contain too few red blood cells and platelets. Puiggros A, Venturas M, Salido M, Blanco G, Fernandez-Rodriguez C, Collado R, Valiente A, Ruiz-Xivill N, Carri A, Ortuo FJ, Luo E, Calasanz MJ, Ardanaz MT, Pin M, Talavera E, Gonzlez MT, Ortega M, Marugn I, Ferrer A, Gimeno E, Bellosillo B, Delgado J, Hernndez J, Hernndez-Rivas JM, Espinet B; Grupo Cooperativo Espaol de Citogentica Hematolgica (GCECGH); Grupo Espaol de Leucemia Linftica Crnica (GELLC). Dealing with an incurable illness is never easy. 2014 Sep;53(9):788-97. doi: 10.1002/gcc.22188. When a person has lymphocytic leukemia, white blood cells become leukemia cells, which can spread into the blood and other parts of the body. 80% of patients with Del (17p) harbor mutations of the remaining TP53 allele. This scale has 5 prognostic factors that doctors can use to predict your outlook. Importance of genetics in chronic lymphocytic leukemia. It also has the advantage of reducing the potential for side effects from treatments. Older adults are more likely to have CLL than others, with 70 years being the average age of diagnosis. Chronic Lymphocytic Leukemia Survival Rate. Nupam A. Patel, MD:When we look at flow cytometry and we get a population that is monoclonal and we're looking at a B-cell population which also expresses CD5, the 2 things that definitely come into mind are chronic lymphocytic leukemia [CLL] and mantle cell lymphoma. Chronic lymphocytic leukemia (CLL) is the most common leukemic disease in elderly patients. abnormalities detected by Fluorescence In situ Hybridization in CLL patients and represent a good prognostic marker with 60% of patients alive after 5 years as compared with 27% for patients with a normal FISH analysis. Read our, Chronic Lymphocytic Leukemia Survival Rate, Coping and Support for Chronic Lymphocytic Leukemia. Furthermore, the size of deletion of the long arm of chromosome 13 (13q) has a remarkable effect on its prognosis and therapeutic intervention. Transcript: William Wierda, MD, PhD: We've done quite a bit of work with prognostic factors in CLL and looked at predictive markers for time-to-first-treatment, predictive markers for how . Copyright 2022 CLL Society, Inc. All rights Reserved. Chronic Lymphocytic Leukemia: Prognosis and Outlook. Bethesda, MD 20894, Web Policies Keywords: chronic lymphocytic leukemia (CLL); diagnosis; prognosis; treatment; evolution; state-of-the-art 1. The association between base line characteristics, 12 month minimal residual disease (MRD) status as detected by flow cytometry with PFS and OS was assessed using univariate Cox proportional hazards model on all patients. Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). . The Rai system divides CLL into 5 stages: Decades later, physicians still use the Rai stages as a way of describing the level of risk from CLL for each patient. based on chromosome mutations. The term "lymphocytic" in chronic lymphocytic . Whenever possible, try to exercise and stay active. Corresponding 10-year age-adjusted relative survival rates were 47.3% and 72.5% for males and 58.2% and 78.7% for females. -, Blood. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome. Unauthorized use of these marks is strictly prohibited. By Corey Whelan Epub 2017 Jun 6. How is chronic lymphocytic leukemia staged? Thank you, {{form.email}}, for signing up. Stages I and II are intermediate-risk. This underscores the importance of retesting for this aberration at clinical progression since it has therapeutic implications. Tam CS, Shanafelt TD, Wierda WG, et al. How Chronic Lymphocytic Leukemia (CLL) Is Staged, Small Lymphocytic Lymphoma: Overview and More, An Overview of Chronic Lymphocytic Leukemia, Major Differences Between Leukemia and Lymphoma. CLL: Therapy, excluding Transplantation, https://doi.org/10.1182/blood.V130.Suppl_1.5337.5337. Thank you for submitting a comment on this article. Self-care is more than just a catchphrase. You might see this written as del(13q), del(11q), or del(17p). Remember also to leave time for other important things, including family, friends, and interests. (2019). CLL has a very high incidence rate in people older than 60 years. Its important to remember that relative survival rates are estimates based on data compiled from large numbers of people with a common diagnosis. We also use third-party cookies that help us analyze and understand how you use this website. It can result in growth and development delays, low muscle tone, abnormal facial features, poor cognitive skills, and hearing/vision impairment. We avoid using tertiary references. Douglas A. Nelson, MD, is a board-certified oncologist and hematologist who previously served for 13 years as a physician in the US Air Force. Median OS was not reached. 52.1% of the patients with CLL harbored 13q deletion, which was significantly higher than that of other BCLPDs (p < 0.001). People with CLL have too many lymphocytes in their blood. Clipboard, Search History, and several other advanced features are temporarily unavailable. Ann Clin Lab Sci. For you, it may include pursuing meditation and yoga or eating healthy, organic food. Moreover, research into the 13q14 deletion has also provided new insights into the molecular genetics and pathways that interact in such a way, making it possible to transform healthy cells into malignant cells in an entirely new fashion with a complete disregard to its original form, resulting in CLL. What are the types of chronic lymphocytic leukemia? The four most common chromosomal aberrations that are detected using FISH studies at diagnosis are: 1) Deletions on the long arm of chromosome 13 (del (13q14)) (present in 55%), 2) Deletions on the long arm of chromosome 11 (del (11q23)) (present in 18%), 4) Deletions on the short arm of chromosome 17 (del(17p)) (present in 7% at diagnosis). Please check for further notifications by email. having changes to the TP53 gene. However a sizeable number of such patients do progress with a decreased progression free survival (PFS) and overall survival (OS). Vaccine therapy. 2014;7(1):321. Net survival represents the probability of surviving cancer in the absence of other causes of death. Chronic lymphocytic leukemia - cancer stat facts. Therefore, if better treatments have become available in the following 5 years, people who have had a recent diagnosis may find the survival rates have improved. Blood. This website uses cookies to improve your experience while you navigate through the website. Gaidano G, Rossi D. Hematology Am Soc Hematol Educ Program. Percentage of del(13q) >50% had no impact on PFS. Mutations driving CLL and their evolution in progression and relapse. People with CLL may not have any symptoms for years. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). (2018). Burger: Novartis: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses; Janssen: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses; Gilead: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses, Research Funding; TG Therapeutics: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses, Research Funding; Pharmacyclics LLC, an AbbVie Company: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses, Research Funding. Fonseca R, Oken MM, Harrington D, Bailey RJ, Van Wier SA, Henderson KJ, Kay NE, Van Ness B, Greipp PR, Dewald GW. One type of CLL progresses very slowly, and a person may not need treatment for some time. Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow the spongy tissue inside bones where blood cells are made. During the watch-and-wait period, youll see your doctor regularly for examinations and blood draws. See this image and copyright information in PMC. Chronic lymphocytic leukemia - cancer stat facts. 2018 Jun 21;131(25):2745-2760. doi:10.1182/blood-2017-09-806398. First-line chemoimmunotherapy with FCR has induced long-term remissions and improvement in overall survival in fit patients with CLL with mutated IGHV. Hematol Oncol Clin North Am. The anomaly is observed predominantly in older patients (average age 62.5 years; range 27-90). Accessibility However, survival rates are only ever an estimate. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. The median survival times (the time by which point half of the patients are alive, the other half dead) for the groups with 17p deletion, 11q deletion, 12q trisomy, normal karyotype, and 13q deletion as the sole abnormality were 32, 79, 114 . Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy. Gene immunotherapy of chronic lymphocytic leukemia: a phase I study of intranodally injected adenovirus expressing a chimeric CD154 molecule. This cookie is set by GDPR Cookie Consent plugin. Tests for chronic lymphocytic leukemia. If patients with mutated IGHV have the presence of VH3-21 usage, their prognosis is inferior to mutated IGHV without VH3-21. Your comment will be reviewed and published at the journal's discretion. This may be from friends, family, or community groups. The Worlds Leading Authority for Chronic Lymphocytic Leukemia Patients, Support Groups |Newsletter Sign Up | Donate Now, Home CLL Information & Management Newly Diagnosed CLL Testing & Imaging Test Before Treat Prognostic Factors in CLL. Incurable, invisible and inconclusive: watchful waiting for chronic lymphocytic leukaemia and implications for doctor-patient communication. Patients whose absolute lymphocyte count (ALC) takes more than 12 months to double have a better prognosis than those whose lymphocyte count takes less than 12 months to double. INTRODUCTION: Chronic lymphocytic leukemia (CLL) with deletion 13q (del13q) has historically better outcome after chemotherapy. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. The sharp decline in life expectancy with time is largely due to the high percentage of older people in the group. The site is secure. This statistic does not take treatments or responses to treatments into account and is not predictive of what will happen in your situation. Is exercise more effective than medication for depression and anxiety? This means that about 83% of people diagnosed with CLL will survive for at least 5 years. Epub 2014 Jun 10. Last medically reviewed on January 9, 2023, Indolent chronic lymphocytic leukemia is a slow-progressing blood and bone marrow cancer. Some studies have shown that combination chemoimmunotherapy, containing alkylating agents may overcome the negative prognostic implications of del11q. Even so, its important to let your doctor know if you have any CLL symptoms. However, hope is always possible. Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome. Data compiled by the National Cancer Institute (NCI) from 2011 to 2017 indicate that the five-year relative survival rate for CLL is 87.2%.

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